1. CLINICAL SIGNIFICANCE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN A COHORT OF JUVENILE IDIOPATHIC ARTHRITIS.
- Author
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Militaru, Andrea Somogyi, Mărginean, Otilia, Dăescu, Camelia, Pienar, Corina, Adrian, Crăciun, Stroescu, Ramona, Chiru, Daniela, Ioan, Sabău, and Puiu, Maria
- Subjects
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JUVENILE idiopathic arthritis , *IMMUNOGLOBULINS , *RHEUMATOID arthritis , *SERUM , *CHEMILUMINESCENCE immunoassay , *PATIENTS - Abstract
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are considered to be specific for rheumatoid arthritis. The aim of the study consists in assessment of prevalence and clinical significance of anti-CCP antibodies in a cohort of juvenile idiopathic arthritis (JIA). In 55 patients with JIA, and a age and sex-matched control group (21 children with no articular sign) IgG anti-CCP antibodies were measured in serum using a commercial chemiluminescent immunoassay (CMIA) method (Architect ABBOTT). Positive anti-CCP values (above the 5U/ml cut-off value of the method) were found in 5 patients (9.1%). Statistical significant positive correlation had been found between anti-CCP antibodies titer and acute phase reactants, disease activity score and radiographic damage, respectively. Reevaluation after 3 months of the anti-CCP antibodies titer revealed statistical significant change. Anti-CCP is less prevalent in JIA than in rheumatoid arthritis, but its positivity denotes an erosive course of disease. [ABSTRACT FROM AUTHOR]
- Published
- 2013