1. Maternal age, infant age, feeding options, single/multiple pregnancy, type of twin sets and mother-to-child transmission of HIV.
- Author
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Nkenfou CN, Temgoua ES, Ndzi EN, Mekue LCM, Ngoufack MN, Dambaya B, Anoubissi JD, Domkam I, Elong E, Fainguem N, Thèze J, Colizzi V, Bissek ACZK, and Ndjolo A
- Subjects
- Adult, Antiretroviral Therapy, Highly Active, Cameroon epidemiology, Female, HIV Infections transmission, Humans, Infant, Infant, Newborn, Male, Maternal Age, Mothers, Pregnancy, Pregnancy, Multiple, Risk Factors, Anti-HIV Agents therapeutic use, Breast Feeding adverse effects, HIV Infections drug therapy, Infectious Disease Transmission, Vertical prevention & control, Nevirapine administration & dosage, Pregnancy Complications, Infectious drug therapy
- Abstract
Background: Some risk factors for mother-to-child transmission (MTCT) of HIV have been identified. To further reduce MTCT, other risk factors were evaluated., Materials and Methods: A retrospective study on early infant diagnosis was conducted. Two-sided chi-square test was used to assess associations with infant HIV status., Results: A total of 15 233 HIV-infected mothers and 15 404 infants were recruited. MTCT rate was 9.34%. Only 3.8% of infants born to mothers on antiretroviral treatment were infected. Under nevirapine, 4.1% of infants were infected. MTCT increased with infant' age at testing. Younger mothers tend to transmit more HIV (P = 0.003). More children were infected in single pregnancies compared with multiple pregnancies, P < 0.001. There were more infections in male-female twins' sets (P = 0.037)., Conclusions: Maternal age, type of pregnancy and twins' sets are new MTCT risk factors. Strategies to further decrease transmission through family planning, pre/post natal consultations and clinical practices are needed., (© The Author(s) [2018]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2019
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