1. Therapy for Ocular Toxoplasmosis.
- Author
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de-la-Torre, Alejandra, Stanford, Miles, Curi, Andre, Jaffe, Glenn J., and Gomez-Marin, Jorge E.
- Subjects
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OCULAR toxoplasmosis , *ANTI-infective agents , *CO-trimoxazole , *CLINDAMYCIN , *DEXAMETHASONE , *META-analysis , *CLINICAL trials , *THERAPEUTICS - Abstract
Purpose: To review current evidence for the treatment of ocular toxoplasmosis (OT). Design: Narrative review and expert recommendations. Methods: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert recommendations were analyzed. Results: Numerous observational studies suggest a benefit of short-term antimicrobial therapy for toxoplasmic retinochoroiditis in immunocompetent patients, although its efficacy has not been proven in randomized clinical trials. A randomized clinical trial revealed that intermittent trimethoprim/sulfamethoxazole treatment could decrease the rate of recurrence in high-risk patients. Intravitreal injection of clindamycin and dexamethasone was an acceptable alternative to the classic treatment for OT in a randomized clinical trial. Conclusions: Opinions about therapy differ and controversy remains about its type, efficacy, and length. Intravitreal therapy may be promising for OT. A recent description of the presence of parasitemia in patients with active and inactive ocular toxoplasmosis raises new questions that need to be explored. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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