1. (+)- and (-)-Tedanine, a pair of new enantiomeric indolone alkaloids from the marine sponge Tedania sp.
- Author
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Guo, Ze-Jie, Liang, Hui-Xian, Lian, Xiao-Ying, Liao, Xiao-Jian, Xing, Xi-Wen, Xu, Shi-Hai, and Zhao, Bing-Xin
- Subjects
HIGH performance liquid chromatography ,ALKALOIDS ,NUCLEAR magnetic resonance spectroscopy ,STAPHYLOCOCCAL diseases ,ACINETOBACTER infections ,MICROBIAL sensitivity tests ,RESEARCH funding ,THIN layer chromatography ,ANALYTICAL biochemistry ,ENTEROCOCCAL infections ,STAPHYLOCOCCUS aureus ,BIOLOGICAL products ,ANTI-infective agents ,PSEUDOMONAS diseases ,CELL lines ,MOLECULAR structure ,SPECTRUM analysis ,ENTEROCOCCUS faecium ,ESCHERICHIA coli diseases ,MASS spectrometry ,COLLECTION & preservation of biological specimens ,BIOLOGICAL assay ,MARINE animals ,PSEUDOMONAS ,PHARMACODYNAMICS - Abstract
(+)- and (-)-Tedanine [(+)-1 and (-)-1], a pair of new enantiomeric indolone alkaloids, along with nine compounds (2–10) were isolated from the marine sponge Tedania sp. The structures of (+)-1 and (-)-1 including absolute configurations were determined by spectroscopic analysis and quantum chemical calculation. Compounds (+)-1 and (-)-1 were the first examples of indolone alkaloids isolated from this genus. In addition, the cytotoxic and antibacterial activities of these compounds were also evaluated. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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