1. Synthesis of some novel pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives as potential antimicrobial agent.
- Author
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Sureja, Dipen K., Dholakia, Sandip P., and Vadalia, Kantilal R.
- Subjects
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PYRAZOLES , *HETEROCYCLIC compounds synthesis , *PYRIMIDINE synthesis , *CHEMICAL derivatives , *ANTI-infective agents , *HETEROCYCLIC compounds - Abstract
Objectives: The aim of the present work was to synthesize a novel series of pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives and evaluate their in vitro antimicrobial activity. Methods: Cyclization of an ortho-amino ester of 1-(2,4-dinitrophenyl)pyrazole with various aliphatic/aromatic nitriles under different reaction conditions such as conventional and microwave assisted synthesis, provided pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives. All the synthesized compounds were evaluated in vitro for their antimicrobial activity against selected bacteria and fungi by agar well diffusion method. Results: All newly synthesized compounds were characterized using spectral and elemental analysis. Compounds 2e, 2f, and 2g showed significant antimicrobial activity as compared to standard drugs used. Conclusion: The newly synthesized compounds could be useful templates for the design and optimization of more active analogs as a possible antimicrobial agent. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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