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Clerodendrum formicarum Gürke from the Lamiaceae family is a Cameroonian medicinal plant. The crude methanol, methanol residual and ethyl acetate extracts of leaves have been phytochemically studied using chromatography column to afford four compounds; two new flavones glycoside: clerodendronone 1a ( 3 ) and clerodendronone 1b ( 4 ) along with two known compounds: 5,7-dihydroxy-4'-methoxyflavone ( 1 ) and 5-hydroxy-7,4'-dimethoxyflavone ( 2 ). Compound structures have been elucidated on the basis of their spectroscopy data and with literature information. The anti-microbial activities of extracts and three isolated compounds were performed. The antibacterial activity was evaluated against four gram positive, five gram negative and three fungus. Clerodendronone 1b ( 4 ) showed good antibacterial activity against bacterial gram negative Shigella flexineri NR518 (MIC = 62.5 μg/ml) and moderate activity against Staphylococcus aureus NR46374 (MIC = 250 μ/ml). The ethyl acetate extract recorded good antibacterial activity against Staphylococcus aureus NR46003 (MIC = 125 µg/ml) and Staphylococcus aureus NR46374 (MIC = 125 μg/ml).