1. Biocompatible 3D Matrix with Antimicrobial Properties.
- Author
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Ion A, Andronescu E, Rădulescu D, Rădulescu M, Iordache F, Vasile BȘ, Surdu AV, Albu MG, Maniu H, Chifiriuc MC, Grumezescu AM, and Holban AM
- Subjects
- Benzofurans chemistry, Cell Line, Cell Survival, Collagen chemistry, Durapatite chemistry, Humans, Materials Testing, Microbial Sensitivity Tests, Microscopy, Electron, Transmission, Spectroscopy, Fourier Transform Infrared, Tissue Engineering, Tissue Scaffolds chemistry, X-Ray Diffraction, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Biocompatible Materials chemistry, Biocompatible Materials pharmacology
- Abstract
The aim of this study was to develop, characterize and assess the biological activity of a new regenerative 3D matrix with antimicrobial properties, based on collagen (COLL), hydroxyapatite (HAp), β-cyclodextrin (β-CD) and usnic acid (UA). The prepared 3D matrix was characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Microscopy (FT-IRM), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD). In vitro qualitative and quantitative analyses performed on cultured diploid cells demonstrated that the 3D matrix is biocompatible, allowing the normal development and growth of MG-63 osteoblast-like cells and exhibited an antimicrobial effect, especially on the Staphylococcus aureus strain, explained by the particular higher inhibitory activity of usnic acid (UA) against Gram positive bacterial strains. Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering.
- Published
- 2016
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