1. Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin.
- Author
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Sahu PK, Sahu PK, Gupta SK, Thavaselvam D, and Agarwal DD
- Subjects
- Anti-Infective Agents chemistry, Anti-Infective Agents toxicity, Bacteria drug effects, Cell Line, Tumor, Chemistry Techniques, Synthetic, Curcumin chemistry, Curcumin toxicity, Fungi drug effects, Humans, Microbial Sensitivity Tests, Structure-Activity Relationship, Anti-Infective Agents chemical synthesis, Anti-Infective Agents pharmacology, Benzothiazoles chemistry, Benzylidene Compounds chemistry, Curcumin chemical synthesis, Curcumin pharmacology, Pyrazoles chemistry
- Abstract
A novel, one-pot, simple, efficient procedure for 4H-pyrimido[2,1-b]benzothiazole (4a-h), pyrazole (6a-d) and benzylidene (7a-d) derivatives of curcumin under solvent and solvent free conditions in microwave with good yield is have been synthesized. The synthesized compounds were evaluated for their antibacterial activity against gram-positive and gram-negative bacteria viz. Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli, Bacillus cereus and Providencia rettgeri and antifungal activity against fungi viz Aspergillus niger, Aspergillus fumigates, Aspergillus flavus. Detailed mechanistic study shows reaction proceeds through Knoevenagel type intermediate 3a which has been suggested as key intermediate for reaction (Fig. 3)., (Copyright © 2012 Elsevier Masson SAS. All rights reserved.)
- Published
- 2012
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