1. Photodynamic antimicrobial activity of hypocrellin A
- Author
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Su, Yujie, Sun, Jun, Rao, Shengqi, Cai, Yujie, and Yang, Yanjun
- Subjects
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PHOTOCHEMOTHERAPY , *ANTI-infective agents , *PERYLENE , *PHOTOSENSITIZERS , *MICROBIAL cell cycle , *QUINONE , *ANTINEOPLASTIC agents , *ESCHERICHIA coli , *GRAM-negative bacteria - Abstract
Abstract: Antimicrobial photodynamic therapy is a recently developed therapeutic option that combines a non-toxic photosensitizer with harmless visible light to damage the microbial cell. Hypocrellin A (HA), a natural occurring lipid-soluble perylenequinone pigment, has gained considerable interest since its anticancer and antiviral activities have been reported. Here, we examined the antimicrobial activity of HA against Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Salmonella typhimurium). The results indicate that HA has a photodynamic antimicrobial activity against both Gram-positive and Gram-negative bacteria when CaCl2 or MgCl2 was employed. A loose binding has been established between HA and the organisms. Molecular oxygen is significantly involved in the photodynamic action of HA. Furthermore, HA maintains a photodynamic activity in terms of both types I and II reactions. Our results confirm the potential of HA to be used as a photosensitizer in antimicrobial photodynamic therapy. [Copyright &y& Elsevier]
- Published
- 2011
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