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Background: Pluchea quitoc DC. (Asteraceae), a medicinal plant known as "quitoco," "caculucage," "tabacarana" and "madreβcravo," is indicated for inflammatory conditions such as bronchitis, arthritis and inflammation in the uterus and digestive system. Objective: This study evaluated the analgesic and antiβinflammatory activities of the triterpenes compounds obtained from P. quitoc aerial parts. Materials and Methods: The triterpenes compounds β amyrin, taraxasterol and pseudoβtaraxasterol in a mixture (T); ββamyrin, taraxasterol and pseudoβtaraxasterol acetates in a mixture (Ta); ββamyrin, taraxasterol, pseudoβtaraxasterol acetates in a mixture with ββamyrin, taraxasterol and pseudoβtaraxasterol myristates (Tafe) were analyzed in the models of nociception and inflammation. The evaluation of antinociceptive activity was carried out by the acetic acidβinduced writhing and tailβflick tests while leukocyte migration to the peritoneal cavity was used for antiβinflammatory profile. Results: The oral administration of T or Tafe (40 mg/kg and 70 mg/kg) and Ta (70 mg/kg) to mice reduced acetic acidβinduced writhing. The tailβflick response of mice was not affected by T or Tafe (40 mg/kg). T or Tafe (40 mg/kg) and Ta (70 mg/kg) also inhibited peritoneal leukocyte infiltration following the injection of carrageenan. Conclusion: The results demonstrate the antiβinflammatory and peripheral antinociceptive activity of the triterpenes ββamyrin, taraxasterol and pseudoβtaraxasterol that were decreased when these were acetylated; while the acetylated triterpenes in mixture with myristyloxy triterpenes improved this activity. These compounds seem, at least in part, to be related to the plant's reported activity. [ABSTRACT FROM AUTHOR]