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Start Over Topic anti-inflammatory agents, non-steroidal
6 results

1. Sustained ibuprofen release using composite poly(lactic-co-glycolic acid)/titanium dioxide nanotubes from Ti implant surface.

Author

Jia H and Kerr LL

Subjects
Nanotubes ultrastructure, Polylactic Acid-Polyglycolic Acid Copolymer, Prostheses and Implants, Tensile Strength, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Delayed-Action Preparations chemistry, Ibuprofen administration & dosage, Lactic Acid chemistry, Nanotubes chemistry, Polyglycolic Acid chemistry, Titanium chemistry
Abstract

Developing coatings on implant surface as drug carriers can reduce organ toxicity and effectively deliver drug locally to the target compared with the oral approach. Titanium dioxide (TiO2) nanotube has great potential for this application for widely used Ti implants because of its high surface area, ability to promote bone growth, and biocompatibility. However, there are two issues needed to be solved before further advancing TiO2 nanotubes technology as drug carriers: uncontrolled drug release and poor mechanical properties. In this study, a drug carrier using a composite of biodegradable polymer/TiO2 nanotubes is engineered. Ibuprofen is selected as a concept drug because it is a commonly used anti-inflammatory, fever, and pain-reducing drug. In addition, ibuprofen has a very short plasma half-life of only 1-3 h. A simple characterization method is developed to investigate the infiltration of polymer into TiO2 nanotubes. Good infiltration was observed of polymer into TiO2 nanotubes. The synthesized drug carrier demonstrated much better sustained drug release profiles for ibuprofen of 5 days (low-molecular-weight polymer) and 9 days (high-molecular-weight polymer) compared with 30 min of pure TiO2 nanotubes. The drug carrier also exhibited much improved mechanical strength and flexibility compared with pure TiO2 nanotubes., (Copyright © 2013 Wiley Periodicals, Inc.)

Published
2013
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2. Comparison of the antiinflammatory effects of Drosera rotundifolia and Drosera madagascariensis in the HET-CAM assay.

Author

Paper DH, Karall E, Kremser M, and Krenn L

Subjects
Allantois drug effects, Animals, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Biological Assay, Chick Embryo, Dose-Response Relationship, Drug, Humans, Plant Components, Aerial, Plant Extracts administration & dosage, Plant Extracts therapeutic use, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Drosera, Inflammation prevention & control, Phytotherapy, Plant Extracts pharmacology
Abstract

The antiinflammatory effects of ethanol and aqueous extracts from Drosera rotundifolia and from Drosera madagascariensis were compared in vivo in the HET-CAM assay. Both extracts from D. rotundifolia and the ethanol extract from D. madagascariensis showed remarkable efficacy at doses of 500 microg/pellet. The inhibition of the inflammation by the extracts was stronger than that by 50 microg hydrocortisone/pellet. In contrast, there was only a very weak effect observed at a dose of 500 microg/pellet of the water extract from D. madagascariensis. The chemical analyses of the extracts showed that the effect cannot be attributed to naphthoquinones, but might be due to flavonoids. Ellagic acid obviously plays an important role in the antiangiogenic effect of the Drosera extracts., ((c) 2005 John Wiley & Sons, Ltd.)

Published
2005
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3. Comparison of the antiinflammatory effects ofDrosera rotundifolia andDrosera madagascariensis in the HET-CAM assay

Author

Liselotte Krenn, Michaela Kremser, Elisabeth Karall, and D. H. Paper

Subjects
Drosera madagascariensis, Drosera, Flavonoid, Chick Embryo, Pharmacognosy, law.invention, chemistry.chemical_compound, Allantois, law, Botany, Animals, Humans, Inflammation, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, biology, Traditional medicine, Plant Extracts, Anti-Inflammatory Agents, Non-Steroidal, Plant Components, Aerial, biology.organism_classification, Drosera rotundifolia, chemistry, Polyphenol, Biological Assay, Phytotherapy, Ellagic acid
Abstract

The antiinflammatory effects of ethanol and aqueous extracts from Drosera rotundifolia and from Drosera madagascariensis were compared in vivo in the HET-CAM assay. Both extracts from D. rotundifolia and the ethanol extract from D. madagascariensis showed remarkable efficacy at doses of 500 microg/pellet. The inhibition of the inflammation by the extracts was stronger than that by 50 microg hydrocortisone/pellet. In contrast, there was only a very weak effect observed at a dose of 500 microg/pellet of the water extract from D. madagascariensis. The chemical analyses of the extracts showed that the effect cannot be attributed to naphthoquinones, but might be due to flavonoids. Ellagic acid obviously plays an important role in the antiangiogenic effect of the Drosera extracts.

Published
2005
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4. Chemical composition of the essential oil of Phlomis linearis Boiss.Bal., and biological effects on the CAM-assay: a safety evaluation

Author

Mehmet Yaşar Dadandi, D. H. Paper, Kemal Hüsnü Can Başer, Betül Demirci, Gerhard Franz, Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Demirci, Betül, and Başer, K. Hüsnü Can

Subjects
Turkey, General Biochemistry, Genetics and Molecular Biology, Gas Chromatography-Mass Spectrometry, law.invention, Phlomis, Sesquiterpenes, Germacrane, law, Allantois, Botany, Oils, Volatile, Animals, Phlomis Linearis, Cam-Assay, Chemical composition, Phlomis linearis, Essential oil, Polycyclic Sesquiterpenes, biology, Traditional medicine, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Biological activity, Chorion, biology.organism_classification, Essential Oil, Lamiaceae, Cattle, Gas chromatography–mass spectrometry, Hydro distillation, Cam assay, Sesquiterpenes
Abstract

WOS: 000188262800014, PubMed ID: 14713159, Phlomis linearis Boiss. & Bal. of the Lamiaceae family growing in central, east and southeast Anatolia is an endemic species for Turkey. The essential oil obtained from the aerial parts by hydro distillation was subsequently analyzed by GC/MS. The main components of the oil were found as beta-caryophyllene (24.2%), germacrene D (22.3%) and caryophyllene oxide (9.2%), among 49 identified compounds, representing 94.5% of the total essential oil. The overall biological activity of the essential oil (100 mug/pellet) was tested on the chorioallantoic membrane (CAM) of the fertilized hen's egg in order to examine the anti-angiogenic and anti-inflammatory activity. None of the tests showed pronounced activity, toxicity or irritation at the tested concentration.

Published
2004

5. Can you recognize and respond to von Willebrand disease?

Author

Renee Paper

Subjects
Advanced and Specialized Nursing, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Estrogens, Assessment and Diagnosis, Emergency Nursing, LPN and LVN, Critical Care Nursing, Bioinformatics, medicine.disease, Nurse's Role, Antifibrinolytic Agents, Hemostatics, Patient Care Planning, von Willebrand Diseases, Patient Education as Topic, Adaptation, Psychological, Von Willebrand disease, Medicine, Humans, Deamino Arginine Vasopressin, Blood Coagulation Tests, business, Progesterone
Published
2003

6. Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women

Author

Agnès Fournier, Marc J. Gunter, Gianluca Severi, Manon Cairat, Laure Dossus, Marie Al Rahmoun, Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France, International Agency for Cancer Research (IACR), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Gustave Roussy (IGR), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Ligue Contre le Cancer Mutuelle Générale de l'Education Nationale, MGEN Institut Gustave-Roussy Institut National de la Santé et de la Recherche Médicale, Inserm, Ligue Contre le Cancer (support for the E3N cohort and PhD fellowship to Manon Cairat). Acknowledgements Disclaimer, and The research was carried out using data from the Inserm (French National Institutes for Health and Medical Research) E3N cohort, which was established and maintained with the support of the Mutuelle Générale de l’Education Nationale (MGEN), Gustave Roussy, and the French League against Cancer (LNCC). We are grateful to the study participants for their continued participation and to medical practitioners for providing pathology reports. We also thank all members of the E3N-EPIC study group, in particular Rafika Chaït, Ghizlane Esselma, Marie Fangon, Pascale Gerbouin-Rérolle, Lyan Hoang, Roselyn Gomes and the data management team, and Amandine Gelot for data management and/or technical assistance. The work reported in this paper was performed during Agnès Fournier’s term as a Visiting Scientist at the International Agency for Research on Cancer.

Subjects
medicine.medical_specialty, Proton pump inhibitors, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Comorbidity, Lower risk, lcsh:RC254-282, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Risk Factors, Surveys and Questionnaires, Internal medicine, medicine, Humans, Medical history, Prospective Studies, Prospective cohort study, Aged, Proportional Hazards Models, 030304 developmental biology, 0303 health sciences, Aspirin, business.industry, Proportional hazards model, Incidence, Incidence (epidemiology), Anti-Inflammatory Agents, Non-Steroidal, Hazard ratio, Nonsteroidal anti-inflammatory drugs, Middle Aged, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Postmenopausal women, 3. Good health, Postmenopause, 030220 oncology & carcinogenesis, Female, France, business, Research Article, Cohort study
Abstract

BackgroundAlthough anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent.MethodsWe investigated the association between NSAID use and BC incidence in the French E3N prospective cohort, which includes 98,995 women born between 1925 and 1950 and insured by a health insurance plan that covers mostly teachers. Self-reported information on lifestyle and medical history has been collected biennially by questionnaires and matched with data from a drug reimbursement database covering the period 2004–2014. Women who self-reported current NSAID use in the 2000 or 2002 questionnaires or with at least two reimbursements in any previous 3-month period were defined as exposed to NSAIDs. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for the association of NSAID use with BC risk.ResultsIn the current analysis, 62,512 postmenopausal women were followed between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 2864 incident BC). In multivariable models, there was no statistically significant association between NSAID use and BC risk [HR = 1.00 (0.92–1.08), compared with non-exposed women]. The NSAID-BC associations did not differ by NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and dose of use. However, a statistically significant interaction was observed by proton pump inhibitor (PPI) drug use (Pinteraction = 0.01) whereby a decreased risk of BC with NSAID use was only observed among women who also used PPI before.ConclusionOnly women who used NSAIDs after having used PPI had a lower risk of BC. This result is novel and requires replication in other studies.

Published
2020
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