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Objectives: The electro-oxidation behavior of the non-steroidal anti-inflammatory drug tenoxicam (TX) was studied on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) by cyclic voltammetry, differential pulse voltammetry (DPV), and square wave voltammetry (SWV). Materials and Methods: The GCE was modified with MWCNT for sensitive determination of TX by voltammetric methods. Results: The current peaks for TX occurred at around 0.520 V for DPV and 0.570 V for SWV when the potential was scanned in the positive direction. The oxidation process of TX showed irreversible and diffusion-controlled behavior. The linear responses were obtained in the range from 2×10-7 to 1×10-5 M with the limit of detection (LOD) 1.43×10-9 for DPV and from 8×10-9 to 8×10-6 with the LOD 9.97×10-10 for SWV in 1 M acetate buffer solution at pH 5.5. Conclusion: Fully validated DPV and SWV were successfully applied for the determination of TX from pharmaceutical dosage form and yielded satisfying results. [ABSTRACT FROM AUTHOR]

A multiwalled carbon nanotubes (MWCNTs) modified carbon paste electrode (CPE) was prepared for voltammetric determination of antiinflammatory drug nimesulide (NIM). The electro-oxidation of NIM was exhibited irreversible and diffusion controlled process with MWCNTs modified CPE. The linear response between peak current and concentration in the quantitative determination of NIM by differential pulse voltammetry in 0.1 M phosphate buffer solution (PBS) at pH 5.0 obtained in the range of the concentration from 6×10-8 -1×10-5 M with limit of detection (LOD) 1.07×10-9 M and limit of quantification (LOQ) 3.24×10-9 M. Differential pulse voltammetry was developed according to linear response of NIM with high selectivity, precision, accuracy using modified electrode was successfully applied to the determination of NIM in pharmaceuticals and human serum samples. [ABSTRACT FROM AUTHOR]