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Start Over Descriptor "isocordoin" Topic anti-oomycete activity
2 results on '"isocordoin"'

1. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin.

Author

Escobar, Beatriz, Montenegro, Iván, Villena, Joan, Werner, Enrique, Godoy, Patricio, Olguín, Yusser, and Madrid, Alejandro

Subjects
*OOMYCETES, *CHEMICAL synthesis, *SAPROLEGNIA, *CHEMICAL derivatives, *MYCELIUM, *NUCLEAR magnetic resonance
Abstract

An efficient synthesis of a series of 4'-oxyalkyl-isocordoin analogues (2-8) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 μg/mL and 75 μg/mL, respectively. The results showed that 4'-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents [ABSTRACT FROM AUTHOR]

Published
2017
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2. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

Author

Joan Villena, Yusser Olguín, Patricio Godoy, Alejandro Madrid, Iván Montenegro, Beatriz Escobar, and Enrique Werner

Subjects
0301 basic medicine, Antifungal Agents, Stereochemistry, Catechols, Pharmaceutical Science, Microbial Sensitivity Tests, Saprolegnia, 01 natural sciences, Article, Isocordoin, Analytical Chemistry, Microbiology, lcsh:QD241-441, 03 medical and health sciences, Minimum inhibitory concentration, Anti-oomycete activity, oxyalkyl derivates, lcsh:Organic chemistry, Saprolegnia sp, Drug Discovery, Physical and Theoretical Chemistry, Mycelium, Oomycete, biology, 010405 organic chemistry, Organic Chemistry, isocordoin, anti-oomycete activity, Spores, Fungal, biology.organism_classification, Saprolegnia parasitica, 0104 chemical sciences, Saprolegnia australis, Spore, 030104 developmental biology, Chemistry (miscellaneous), Inorganic Chemicals, Oxyalkyl derivates, Molecular Medicine
Abstract

Indexación: Web of Science; Scopus. An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents. http://www.mdpi.com/1420-3049/22/6/968

Published
2017

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