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Since the discovery of polyphenolic resins 150 years ago, the study of polymeric compounds named calix[n]arene has continued to progress, and those skilled in the art perfectly know now how to modulate this phenolic ring. Consequently, calix[n]arenes are now used in a large range of applications and notably in therapeutic fields. In particular, the calix[4]arene exhibits multiple possibilities for regioselective polyfunctionalization on both of its rims and offers researchers the possibility of precisely tuning the geometry of their structures. Thus, in the crucial research of new antibacterial active ingredients, the design of calixarenes finds its place perfectly. This review provides an overview of the work carried out in this aim towards the development of intrinsically active prodrogues or metallic calixarene complexes. Out of all the work of the community, there are some excellent activities emerging that could potentially place these original structures in a very good position for the development of new active ingredients. [ABSTRACT FROM AUTHOR]

As part of specific investigations dedicated to the building of a chemical library of calixarenes with anti-infective properties, some H2O-soluble calix[4]arene derivatives incorporating carboxylate groups at the upper rim and heterocycles at the lower rim have been prepared and characterized as have their constitutive functional monomers. In vitro antibacterial testing against Gram-positive and Gram-negative reference strains shows that the derivative with two 5,5′-dicarboxylated 2,2′-bithiazole subunits in alternate positions at the lower rim displays an activity at ca. 70 μ M (128 μg/ml) on S. aureus ATCC 29213. [ABSTRACT FROM AUTHOR]

A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. In order to further research the compound 3a , the crystal structure was detected by X-ray diffraction. Meanwhile, the structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR, elemental analysis and HRMS (ESI) spectroscopy. Image 1 • A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized. • Their antibacterial and antioxidant activities were evaluated. • Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. [ABSTRACT FROM AUTHOR]