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Graphene has emerged as a novel green broad-spectrum antibacterial material, with little bacterial resistance and tolerable cytotoxic effect on mammalian cells. It exerts its antibacterial action via physical damages such as direct contact of its sharp edges with bacterial membranes and destructive extraction of lipid molecules. These damages also include wrapping and photothermal ablation mechanisms. Alternatively, chemical damage of bacteria is caused by oxidative stress with the generation of reactive oxygen species and charge transfer. Furthermore, graphene has been used as a support to disperse and stabilize various nanomaterials, such as metals, metal oxides, and polymers, with high antibacterial efficiency due to the synergistic effect. In addition, graphene-based antibiotic drug delivery platforms have been constructed. Due to the superior antibacterial properties and good biocompatibility, graphene-based nanocomposites have a wide range of applications, such as antibacterial packaging, wound dressing, and water disinfection. In this review, we highlight the antibacterial mechanism of graphene and summarize recent advances related to the antibacterial activity of graphene-based materials. Many of the recent application examples are further discussed. We hope that this review provides valuable insight, stimulates broader concerns, and spurs further developments in this promising field. [ABSTRACT FROM AUTHOR]

The biofilm resistance of microorganisms has severe economic and environmental implications, especially the contamination of facilities associated with human life, including medical implants, air-conditioning systems, water supply systems, and food-processing equipment, resulting in the prevalence of infectious diseases. Once bacteria form biofilms, their antibiotic resistance can increase by 10–1,000-fold, posing a great challenge to the treatment of related diseases. In order to overcome the contamination of bacterial biofilm, destroying the biofilm's matrix so as to solve the penetration depth dilemma of antibacterial agents is the most effective way. Here, a magnetically controlled multifunctional micromotor was developed by using H 2 O 2 as the fuel and MnO 2 as the catalyst to treat bacterial biofilm infection. In the presence of H 2 O 2 , the as-prepared motors could be self-propelled by the generated oxygen microbubbles. Thereby, the remotely controlled motors could drill into the EPS of biofilm and disrupt them completely with the help of bubbles. Finally, the generated highly toxic •OH could efficiently kill the unprotected bacteria. This strategy combined the mechanical damage, highly toxic •OH, and precise magnetic guidance in one system, which could effectively eliminate biologically infectious fouling in microchannels within 10 min, possessing a wide range of practical application prospects especially in large scale and complex infection sites. [Display omitted] • Mechanical damage, highly toxic •OH, and precise magnetic guidance were integrated in one antimicrobial system. • H 2 O 2 was used as the fuel to trigger the high-speed movement of motor and serve as the source of high toxic •OH. • Enhanced antibacterial activities were obtained even for the treatment of drug-resistant bacteria MRSA. • The micro-nano hybrid multifunctional motors developed here are precisely controlled and deeply penetrated. • Motors have strong destructive ability for the treatment of large-scale biofilm EPS even at complex infection sites. [ABSTRACT FROM AUTHOR]