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Background: Infections with pseudomonas have been an important cause of Morbidity and Mortality throughout the history, which makes the treatment challenging every year. The present study was intended to find out the drug resistance pattern of Pseudomonas aeruginosa from various clinical specimens. Materials and methods: The study was conducted during April 2015 to September 2015. One hundred and one strains of Pseudomonas aeruginosa were subjected to antimicrobial susceptibility test by modified Kirby-Bauer disk diffusion method as per CLSI guidelines with Pseudomonas aeruginosa ATCC 27853 as control strain. Results: One hundred and one Strains were isolated from 83 males and 28 females. Majority of the Pseudomonas strains were isolated from ICU (30.63%), followed by Orthopedics (14.41%) and Pediatrics wards (13.51%), Strains were mainly isolated from pus samples (48.65%) followed by urine (20.72%) and sputum sample (13.51%). Majority of the strains were resistant to Aztreonam (70.27%) followed by Ciprofloxacin (54.95%), Amikacin (53.15%), Piperacillin (51.35%), Cefoperazone-sulbactam (50.45%), Gentamycin (49.55%), Cefepime and ceftazidime at 45.95% respectively. While with Piperacillin - Tazobactam we got sensitivity of 63.97% and with Imipenem and Imipenem -EDTA we got sensitivity of 78.38% and 81.08% respectively. Conclusion: We concluded that drug resistance of Pseudomonas was mainly isolated from pus samples of ICU patients, which is therefore an urgent call for the physicians to limit the indiscriminate use of antibiotics. The encouraging finding was its sensitivity to Imipenem and Piperacilin- Tazobactum as an effective antibiotic for the treatment. [ABSTRACT FROM AUTHOR]