1. Prevalence of HTLV-III/LAV in household contacts of patients with confirmed AIDS and controls in Kinshasa, Zaire.
- Author
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Mann JM, Quinn TC, Francis H, Nzilambi N, Bosenge N, Bila K, McCormick JB, Ruti K, Asila PK, and Curran JW
- Subjects
- Acquired Immunodeficiency Syndrome transmission, Adult, Aged, Deltaretrovirus immunology, Democratic Republic of the Congo, Enzyme-Linked Immunosorbent Assay, Female, HIV Antibodies, Humans, Male, Middle Aged, Acquired Immunodeficiency Syndrome epidemiology, Antibodies, Viral analysis, Family
- Abstract
Household members of 46 patients with confirmed acquired immunodeficiency syndrome (AIDS) and 43 human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-seronegative controls from Kinshasa, Zaire, were identified and sought for serologic testing for evidence of HTLV-III/LAV infection. Twenty (9.8%) of 204 case-household members and three (1.9%) of 155 control-household members were HTLV-III/LAV seropositive (relative risk = 5.1; 95% confidence interval, 1.7 to 15.2). Eleven (61.1%) of 18 spouses of patients with AIDS were HTLV-III/LAV seropositive, compared with one (3.7%) of 27 control spouses (relative risk = 16.5; 95% confidence interval, 3.7 to 75.0). Except for spouses, the rate of HTLV-III/LAV seropositivity did not differ significantly between case and control households. Furthermore, for adults in case households who were not spouses, the number seropositive for HTLV-III/LAV was identical to that predicted from sex- and age-specific HTLV-III/LAV seroprevalence rates. These data from Zaire confirm the results of US and European studies of household contacts of infected hemophiliacs and pediatric patients with AIDS.
- Published
- 1986