1. Facilitation of antibody forming responses to viral vaccine antigens in young cats by recombinant baculovirus-expressed feline IFN-gamma.
- Author
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Schijns VE, Scholtes NC, Zuilekom HI, Sanders LE, Nicolson L, and Argyle DJ
- Subjects
- Adjuvants, Immunologic administration & dosage, Animals, Antigens, Viral administration & dosage, Baculoviridae genetics, Calicivirus, Feline immunology, Cats, Interferon-gamma genetics, Rabies Vaccines administration & dosage, Recombinant Proteins, Antibodies, Viral biosynthesis, Interferon-gamma administration & dosage, Viral Vaccines administration & dosage
- Abstract
We assessed the effect of recombinant feline IFN-gamma as vaccine adjuvant for in vivo antibody responses of young 3-month-old kittens to inactivated antigens of rabies and calicivirus, both natural pathogens for cats. When compared to responses following immunization with antigen alone co-administration of baculovirus-expressed cat IFN-gamma significantly enhanced serum antibody titers to both viral antigens; to levels comparable with responses evoked by commonly known saponin and alum adjuvants. Adjuvanticity by feline IFN-gamma was dose-dependent and all doses tested were well tolerated. We conclude that, when further optimized for in vivo delivery, feline IFN-gamma may represent a safe and efficient natural vaccine adjuvant for certain antigens in cats.
- Published
- 2002
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