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Start Over Descriptor "Thrombin -- Structure" Topic antibodies -- structure
1 results on '"Thrombin -- Structure"'

1. Bivalent ligands with long nanometer-scale flexible linkers

Author

Ling Tian and Heyduk, Tomasz

Subjects
Antibodies -- Chemical properties, Antibodies -- Structure, Viral antibodies -- Chemical properties, Viral antibodies -- Structure, Ligand binding (Biochemistry) -- Analysis, Thrombin -- Chemical properties, Thrombin -- Structure, Biological sciences, Chemistry
Abstract

A simple strategy to prepare aptamer-based ligands with enhanced binding affinities and the anticlotting activities of thrombin bivalent ligands is described. The two aptamer ligands with suboptimal binding properties are covalently linked with a long flexible linker to create a bivalent ligand with significantly improved binding affinity.

Published
2009

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