2 results on '"Danzi, Giambattista"'
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2. Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study
- Author
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Valentina Carubelli, Carlo Lombardi, Marco Metra, Davide Margonato, Massimiliano Gnecchi, Antonio Bellasi, Maurizio Volterrani, Marco Guazzi, Gregorio Zaccone, Riccardo M. Inciardi, Massimo F Piepoli, Mattia Di Pasquale, Laura Adelaide Dalla Vecchia, Francesco Catagnano, Stefano Carugo, Michele Senni, Sergio Leonardi, Vincenzo Nuzzi, Pietro Ameri, Filippo M. Sarullo, Stefano Giovinazzo, Luca Monzo, Rita Camporotondo, Gianfranco Sinagra, Andrea Mortara, Giovanni Provenzale, Daniela Tomasoni, Marco Merlo, Anita Iorio, Maria Teresa La Rovere, Chiara Tedino, Andrea Pozzi, Claudia Canale, Giambattista Danzi, Piergiuseppe Agostoni, Italo Porto, Gloria Maccagni, Massimo Mapelli, Ameri, Pietro, Inciardi, Riccardo M, Di Pasquale, Mattia, Agostoni, Piergiuseppe, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Vecchia, Laura Dalla, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Sinagra, Gianfranco, Tedino, Chiara, Tomasoni, Daniela, Volterrani, Maurizio, Zaccone, Gregorio, Lombardi, Carlo Mario, Senni, Michele, Metra, Marco, Ameri, P, Inciardi, R, Di Pasquale, M, Agostoni, P, Bellasi, A, Camporotondo, R, Canale, C, Carubelli, V, Carugo, S, Catagnano, F, Danzi, G, Dalla Vecchia, L, Giovinazzo, S, Gnecchi, M, Guazzi, M, Iorio, A, La Rovere, M, Leonardi, S, Maccagni, G, Mapelli, M, Margonato, D, Merlo, M, Monzo, L, Mortara, A, Nuzzi, V, Piepoli, M, Porto, I, Pozzi, A, Provenzale, G, Sarullo, F, Sinagra, G, Tedino, C, Tomasoni, D, Volterrani, M, Zaccone, G, Lombardi, C, Senni, M, and Metra, M
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Male ,030204 cardiovascular system & hematology ,Cohort Studies ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Coagulopathy ,80 and over ,Medicine ,030212 general & internal medicine ,Hospital Mortality ,Anticoagulant ,COVID-19 ,d-dimer ,Death ,Thromboembolism ,Tomography ,Aged, 80 and over ,education.field_of_study ,Incidence (epidemiology) ,Incidence ,Respiration ,General Medicine ,Middle Aged ,Pulmonary embolism ,X-Ray Computed ,Hospitalization ,Italy ,Artificial ,Breathing ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,medicine.drug ,medicine.medical_specialty ,Population ,Hemorrhage ,Fibrin Fibrinogen Degradation Products ,03 medical and health sciences ,Tocilizumab ,Internal medicine ,Humans ,D-dimer ,Aged ,Follow-Up Studies ,Pulmonary Embolism ,Respiration, Artificial ,Retrospective Studies ,Tomography, X-Ray Computed ,education ,Original Paper ,business.industry ,medicine.disease ,chemistry ,Heart failure ,Ritonavir ,business ,Kidney disease - Abstract
Background Pulmonary embolism (PE) has been described in coronavirus disease 2019 (COVID-19) critically ill patients, but the evidence from more heterogeneous cohorts is limited. Methods Data were retrospectively obtained from consecutive COVID-19 patients admitted to 13 Cardiology Units in Italy, from March 1st to April 9th, 2020, and followed until in-hospital death, discharge, or April 23rd, 2020. The association of baseline variables with computed tomography-confirmed PE was investigated by Cox hazards regression analysis. The relationship between d-dimer levels and PE incidence was evaluated using restricted cubic splines models. Results The study included 689 patients (67.3 ± 13.2 year-old, 69.4% males), of whom 43.6% were non-invasively ventilated and 15.8% invasively. 52 (7.5%) had PE over 15 (9–24) days of follow-up. Compared with those without PE, these subjects had younger age, higher BMI, less often heart failure and chronic kidney disease, more severe cardio-pulmonary involvement, and higher admission d-dimer [4344 (1099–15,118) vs. 818.5 (417–1460) ng/mL, p p p = 0.06). In multivariate regression, only d-dimer was associated with PE (HR 1.72, 95% CI 1.13–2.62; p = 0.01). The relation between d-dimer concentrations and PE incidence was linear, without inflection point. Only two subjects had a baseline d-dimer Conclusions PE occurs in a sizable proportion of hospitalized COVID-19 patients. The implications of bleeding events and the role of d-dimer in this population need to be clarified. Graphic abstract
- Published
- 2021
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