1. Applications of electrochemical techniques for determination of anticoagulant drug (Rivaroxaban) in real samples
- Author
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A.B. Abdallah, Aya Saher, Ahmed Fathi Salem Molouk, Wael I. Mortada, and Magdi E. Khalifa
- Subjects
Biomedical Engineering ,Biophysics ,Anticoagulants ,Biosensing Techniques ,Electrochemical Techniques ,General Medicine ,Carbon ,Molecular Imprinting ,Molecularly Imprinted Polymers ,Rivaroxaban ,Limit of Detection ,Spectroscopy, Fourier Transform Infrared ,Electrochemistry ,Electrodes ,Biotechnology - Abstract
The electrochemical behavior of rivaroxaban (RIV), a direct Factor Xa inhibitor, was investigated using a glassy carbon electrode (GCE) based on molecularly imprinted polymer (MIP). The MIP was developed by co-polymerization of different monomers (acrylamide and methacrylic acid) with the cross-linker (ethylene glycol dimethacrylate (EGDMA)) in the presence of initiator (potassium persulphate) and RIV as a template. Fourier transform infrared spectroscopy (FT-IR), atomic force microscopy (AFM), energy dispersive X-ray (EDX), and scanning electron microscope (SEM) were used for the characterization of the fabricated polymers. To prepare the potentiometric sensor, the MIP was incorporated in polyvinyl chloride (PVC) in the presence of a plasticizer and coated on the GCE as one layer. While the voltammetric sensor was prepared by drop coating technique, in which the graphene oxide and MIP were deposited on the bare GCE, respectively. Linear response over RIV concentrations in the range of 1.2 × 10
- Published
- 2022
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