1. Review of Direct Oral Anticoagulants and Guide for Effective Drug Utilization.
- Author
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Khachatryan T, Hauschild C, Hoff J, Contractor T, Khachatryan A, Tran H, Matsuo B, Jacobson A, and Hilliard A
- Subjects
- Administration, Oral, Anticoagulants adverse effects, Anticoagulants pharmacology, Antithrombins adverse effects, Antithrombins pharmacokinetics, Dose-Response Relationship, Drug, Drug Monitoring, Drug Utilization, Factor Xa Inhibitors adverse effects, Factor Xa Inhibitors pharmacokinetics, Humans, Anticoagulants therapeutic use, Antithrombins pharmacology, Antithrombins therapeutic use, Factor Xa Inhibitors pharmacology, Factor Xa Inhibitors therapeutic use, Stroke prevention & control
- Abstract
Direct oral anticoagulants (DOACs) have been developed as a viable and in some cases superior alternative to warfarin. These agents have overcome some of the limitations of warfarin, which has a narrow therapeutic window and many food and drug interactions. DOACs have been demonstrated to have a more predictable and reliable pharmacology and, unlike warfarin, do not require frequent monitoring of anticoagulant effect. For these reasons, the use of DOACs is increasing. Despite the many positive attributes of these agents, limitations and contraindications do exist. An understanding of the pharmacology, indications, and contraindications is therefore crucial for effective patient management. We review the available agents to aid in effective drug utilization.
- Published
- 2019
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