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Start Over Descriptor "atrial fibrillation symptoms" Topic anticoagulation
2 results on '"atrial fibrillation symptoms"'

1. Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe

Author

Renate B. Schnabel, Ladislav Pecen, Nargiz Rzayeva, Markus Lucerna, Yanish Purmah, Francisco M. Ojeda, Raffaele De Caterina, and Paulus Kirchhof

Subjects
anticoagulation, atrial fibrillation, atrial fibrillation symptoms, European Heart Rhythm Association score, quality of life, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundLittle is known about the association of atrial fibrillation symptom burden with quality of life and outcomes. Methods and ResultsIn the Prevention of Thromboembolic Events–European Registry in Atrial Fibrillation (n=6196 patients with atrial fibrillation; mean±SD age, 71.8±10.4 years; 39.7% women), we assessed European Heart Rhythm Association score symptoms and calculated correlations with the standardized health status questionnaire (EQ‐5D‐5L). Patients were followed up for atrial fibrillation therapies and outcomes (stroke/transient ischemic attack/arterial thromboembolism, coronary events, heart failure, and major bleeding) over 1 year. Most individuals (92%) experienced symptoms. Correlations with health status and quality of life were modest. In multivariable‐adjusted regression models, the dichotomized European Heart Rhythm Association score (intermediate/frequent versus never/occasional symptoms) was associated with cardioversions (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.01–1.45) and catheter ablation (OR, 1.97; 95% CI, 1.44–2.69), and inversely related with heart rate control (OR, 0.80; 95% CI, 0.70–0.92) and heart failure incidence (OR, 1.65; 95% CI, 1.16–2.34). Anxiety was inversely related with stroke/transient ischemic attack/arterial thromboembolism (OR, 0.55; 95% CI, 0.32–0.93), whereas chest pain related positively with coronary events (OR, 2.45; 95% CI, 1.42–4.22). Fatigue (OR, 1.84; 95% CI, 1.30–2.60), dyspnea (OR, 2.33; 95% CI, 1.63–3.33), and anxiety (OR, 1.72; 95% CI, 1.16–2.55) were associated with heart failure incidence. Palpitations were positively associated with cardioversion (OR, 1.32; 95% CI, 1.08–1.61) and ablation therapy (OR, 2.02; 95% CI, 1.48–2.76). ConclusionsA higher symptom burden, in particular palpitations, predicted interventions to restore sinus rhythm. The score itself had limited predictive value, but its individual components were related to different and specific clinical events, and may thus be helpful to target patient management.

Published
2018
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2. Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe

Author

Ladislav Pecen, Francisco Ojeda, Renate B. Schnabel, Yanish Purmah, Markus Lucerna, Paulus Kirchhof, Raffaele De Caterina, and Nargiz Rzayeva

Subjects
Ablation Techniques, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Health Status, Electric Countershock, Catheter ablation, 030204 cardiovascular system & hematology, Cardioversion, Chest pain, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Predictive Value of Tests, Risk Factors, European Heart Rhythm Association score, Internal medicine, Atrial Fibrillation, medicine, Palpitations, Humans, Arrhythmia and Electrophysiology, 030212 general & internal medicine, Prospective Studies, Registries, anticoagulation, Stroke, Aged, Original Research, Aged, 80 and over, Quality and Outcomes, business.industry, Atrial fibrillation, Middle Aged, medicine.disease, 3. Good health, Europe, Treatment Outcome, quality of life, Heart failure, Cardiology, atrial fibrillation symptoms, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Cardioversions, business
Abstract

Background Little is known about the association of atrial fibrillation symptom burden with quality of life and outcomes. Methods and Results In the Prevention of Thromboembolic Events–European Registry in Atrial Fibrillation (n=6196 patients with atrial fibrillation; mean±SD age, 71.8±10.4 years; 39.7% women), we assessed European Heart Rhythm Association score symptoms and calculated correlations with the standardized health status questionnaire ( EQ ‐5D‐5L). Patients were followed up for atrial fibrillation therapies and outcomes (stroke/transient ischemic attack/arterial thromboembolism, coronary events, heart failure, and major bleeding) over 1 year. Most individuals (92%) experienced symptoms. Correlations with health status and quality of life were modest. In multivariable‐adjusted regression models, the dichotomized European Heart Rhythm Association score (intermediate/frequent versus never/occasional symptoms) was associated with cardioversions (odds ratio [ OR ], 1.21; 95% confidence interval [ CI ], 1.01–1.45) and catheter ablation ( OR, 1.97; 95% CI, 1.44–2.69), and inversely related with heart rate control ( OR, 0.80; 95% CI, 0.70–0.92) and heart failure incidence ( OR, 1.65; 95% CI, 1.16–2.34). Anxiety was inversely related with stroke/transient ischemic attack/arterial thromboembolism ( OR, 0.55; 95% CI, 0.32–0.93), whereas chest pain related positively with coronary events ( OR, 2.45; 95% CI, 1.42–4.22). Fatigue ( OR, 1.84; 95% CI, 1.30–2.60), dyspnea ( OR, 2.33; 95% CI, 1.63–3.33), and anxiety ( OR, 1.72; 95% CI, 1.16–2.55) were associated with heart failure incidence. Palpitations were positively associated with cardioversion ( OR, 1.32; 95% CI, 1.08–1.61) and ablation therapy ( OR, 2.02; 95% CI, 1.48–2.76). Conclusions A higher symptom burden, in particular palpitations, predicted interventions to restore sinus rhythm. The score itself had limited predictive value, but its individual components were related to different and specific clinical events, and may thus be helpful to target patient management.

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