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Your search keyword '"Harrington, Frank"' showing total 2 results
Start Over Author "Harrington, Frank" Topic anticonvulsants
2 results on '"Harrington, Frank"'

1. The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents.

Author

Austin NE, Hadley MS, Harling JD, Harrington FP, Macdonald GJ, Mitchell DJ, Riley GJ, Stean TO, Stemp G, Stratton SC, Thompson M, and Upton N

Subjects
Administration, Oral, Animals, Anticonvulsants pharmacokinetics, Anticonvulsants pharmacology, Dose-Response Relationship, Drug, Drug Design, Naphthyridines pharmacology, Rats, Seizures drug therapy, Seizures prevention & control, Structure-Activity Relationship, Tetrahydroisoquinolines, Anticonvulsants chemical synthesis, Naphthyridines chemical synthesis, Naphthyridines pharmacokinetics
Abstract

Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.

Published
2003
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2. The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents

Author

John D. Harling, Darren Jason Mitchell, Mervyn Thompson, Sharon C Stratton, Graham J. Riley, Nigel E. Austin, Macdonald Gregor James, Geoffrey Stemp, Harrington Frank Peter, Tania O. Stean, Michael S. Hadley, and Neil Upton

Subjects
medicine.drug_class, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Tetrahydroisoquinoline derivatives, Administration, Oral, Carboxamide, Ether, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Seizures, Tetrahydroisoquinolines, Drug Discovery, medicine, Organic chemistry, Animals, Naphthyridines, Molecular Biology, Bicyclic molecule, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Rats, Anticonvulsant Agent, Anticonvulsant, Drug Design, Molecular Medicine, Anticonvulsants
Abstract

Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.

Published
2003

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