1. Monoamine metabolites as predictors of antidepressant response: a critique.
- Author
-
Kelwala S, Jones D, and Sitaram N
- Subjects
- Brain drug effects, Depressive Disorder enzymology, Dopamine beta-Hydroxylase blood, Homovanillic Acid cerebrospinal fluid, Humans, Hydroxyindoleacetic Acid cerebrospinal fluid, Methoxyhydroxyphenylglycol metabolism, Monoamine Oxidase blood, Norepinephrine urine, Normetanephrine urine, Receptors, Adrenergic drug effects, Receptors, Serotonin drug effects, Vanilmandelic Acid urine, Antidepressive Agents therapeutic use, Depressive Disorder drug therapy, Neurotransmitter Agents metabolism
- Abstract
Monoamine metabolite measurements are being increasingly used for making nosological, symptomatological and pharmacological profiles of the affective disorders. A number of unresolved methodological issues question the validity of using baseline metabolite levels for predicting treatment response. Some studies show correlations between baseline metabolite levels and response to treatment with specific antidepressant agents. Effects of antidepressant treatment on metabolite levels may be useful in predicting drug response.
- Published
- 1983
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