1. [Biological activity of selenorganic compounds at heavy metal salts intoxication].
- Author
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Rusetskaya NY and Borodulin VB
- Subjects
- Animals, Antidotes chemistry, Antioxidants chemistry, Cadmium toxicity, Chelating Agents chemistry, Humans, Lead toxicity, Mercury toxicity, Metals, Heavy metabolism, Mitochondria drug effects, Mitochondria metabolism, Mitochondria pathology, Organoselenium Compounds chemistry, Oxidative Stress drug effects, Poisoning metabolism, Poisoning pathology, Reactive Oxygen Species antagonists & inhibitors, Reactive Oxygen Species metabolism, Salts toxicity, Antidotes pharmacology, Antioxidants pharmacology, Chelating Agents pharmacology, Heavy Metal Poisoning, Organoselenium Compounds pharmacology, Poisoning drug therapy, Salts antagonists & inhibitors
- Abstract
Possible mechanisms of the antitoxic action of organoselenium compounds in heavy metal poisoning have been considered. Heavy metal toxicity associated with intensification of free radical oxidation, suppression of the antioxidant system, damage to macromolecules, mitochondria and the genetic material can cause apoptotic cell death or the development of carcinogenesis. Organic selenium compounds are effective antioxidants during heavy metal poisoning; they exhibit higher bioavailability in mammals than inorganic ones and they are able to activate antioxidant defense, bind heavy metal ions and reactive oxygen species formed during metal-induced oxidative stress. One of promising organoselenium compounds is diacetophenonyl selenide (DAPS-25), which is characterized by antioxidant and antitoxic activity, under conditions including heavy metal intoxication.
- Published
- 2015
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