1. Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid.
- Author
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Lat A, Thompson GR 3rd, Rinaldi MG, Dorsey SA, Pennick G, and Lewis JS 2nd
- Subjects
- Adult, Aged, Antifungal Agents therapeutic use, Candidiasis drug therapy, Candidiasis microbiology, Echinocandins therapeutic use, Humans, Lipopeptides therapeutic use, Male, Micafungin, Antifungal Agents pharmacokinetics, Brain metabolism, Echinocandins pharmacokinetics, Lipopeptides pharmacokinetics, Pancreatic Pseudocyst metabolism
- Abstract
We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.
- Published
- 2010
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