1. In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections.
- Author
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Reidenberg BE, Jenkins SG, Crandon JL, Hurlburt E, Tan X, Rhomberg PR, Arends SJR, and Pfaffle A
- Subjects
- Humans, Central Venous Catheters microbiology, Central Venous Catheters adverse effects, Candidiasis microbiology, Candidiasis drug therapy, Candidemia microbiology, Candidemia drug therapy, Thiadiazines pharmacology, Taurine analogs & derivatives, Taurine pharmacology, Microbial Sensitivity Tests, Catheter-Related Infections microbiology, Catheter-Related Infections drug therapy, Catheter-Related Infections prevention & control, Antifungal Agents pharmacology, Candida auris drug effects
- Abstract
Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C . auris isolates. Taurolidine was highly active with a MIC
50 /MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections., Competing Interests: J.L.C., E.H., X.T., and A.P. are all employees of CorMedix Inc.; B.E.R. is a consultant to CorMedix Inc.- Published
- 2024
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