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Your search keyword '"van den Bogaart, Geert"' showing total 1 results
Start Over Author "van den Bogaart, Geert" Topic antigen presentation Topic covid-19
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1. The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19.

Author

Baranov, Maksim V., Bianchi, Frans, and van den Bogaart, Geert

Subjects
COVID-19, COVID-19 treatment, ANTIGEN presentation, T cells, PROTEOLYTIC enzymes
Abstract

The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitro studies and the clinic that apilimod blocks antiviral immune responses. We therefore warn that the immunosuppression observed in many COVID-19 patients might be aggravated by apilimod. [ABSTRACT FROM AUTHOR]

Published
2021
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