1. Conventional CD4 + T cells present bacterial antigens to induce cytotoxic and memory CD8 + T cell responses.
- Author
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Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, and Veiga E
- Subjects
- Animals, Cells, Cultured, Cross-Priming immunology, Cytotoxicity, Immunologic immunology, Immunologic Memory immunology, Immunological Synapses immunology, Mice, Inbred C57BL, Mice, Transgenic, Phagocytosis immunology, Programmed Cell Death 1 Receptor immunology, Antigen Presentation immunology, Antigens, Bacterial immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology
- Abstract
Bacterial phagocytosis and antigen cross-presentation to activate CD8
+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy.- Published
- 2017
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