1. The Immunological Synapse Balances T Cell ReceptorSignaling and Degradation.
- Author
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Lee, Kyeong-Hee, Dinner, Aaron R., Tu, Chun, Campi, Gabriele, Raychaudhuri, Subhadip, Varma, Rajat, Sims, Tasha N., Burack, W. Richard, Wu, Hui, Wang, Julia, Kanagawa, Osami, Markiewicz, Mary, Allen, Paul M., Dustin, Michael L., Chakraborty, Arup K., and Shaw, Andrey S.
- Subjects
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T cell receptors , *ANTIGEN presenting cells , *SYNAPSES , *CELL adhesion molecules - Abstract
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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