1. Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology.
- Author
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Gómez-Rial J, Currás-Tuala MJ, Rivero-Calle I, Gómez-Carballa A, Cebey-López M, Rodríguez-Tenreiro C, Dacosta-Urbieta A, Rivero-Velasco C, Rodríguez-Núñez N, Trastoy-Pena R, Rodríguez-García J, Salas A, and Martinón-Torres F
- Subjects
- Adrenal Cortex Hormones administration & dosage, Adult, Aged, Antibodies, Monoclonal, Humanized administration & dosage, COVID-19, Female, Humans, Hydroxychloroquine administration & dosage, Intensive Care Units, Interleukin-6 blood, Interleukin-6 immunology, Macrophage Activation, Macrophages immunology, Macrophages metabolism, Macrophages pathology, Male, Middle Aged, Monocytes immunology, Monocytes pathology, Patient Admission, SARS-CoV-2, Time Factors, CD163 Antigen, Antigens, CD blood, Antigens, CD immunology, Antigens, Differentiation, Myelomonocytic blood, Antigens, Differentiation, Myelomonocytic immunology, Betacoronavirus immunology, Betacoronavirus metabolism, Coronavirus Infections blood, Coronavirus Infections drug therapy, Coronavirus Infections immunology, Coronavirus Infections pathology, Lipopolysaccharide Receptors blood, Lipopolysaccharide Receptors immunology, Pandemics, Pneumonia, Viral blood, Pneumonia, Viral drug therapy, Pneumonia, Viral immunology, Pneumonia, Viral pathology, Receptors, Cell Surface blood, Receptors, Cell Surface immunology
- Abstract
Background: Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind., Methods: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group., Results: sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time lapsed from admission to sampling, independently of severity group. Treatment with corticoids showed an interference with sCD14 levels, whereas hydroxychloroquine and tocilizumab did not., Conclusions: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a preponderant role for monocyte-macrophage activation in the development of immunopathology of COVID-19 patients., (Copyright © 2020 Gómez-Rial, Currás-Tuala, Rivero-Calle, Gómez-Carballa, Cebey-López, Rodríguez-Tenreiro, Dacosta-Urbieta, Rivero-Velasco, Rodríguez-Núñez, Trastoy-Pena, Rodríguez-García, Salas and Martinón-Torres.)
- Published
- 2020
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