1. Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation.
- Author
-
Juji, T., Watanabe, Y., Ishikawa, Y., Fujiwara, K., Tonami, H., Tanaka, H., Satake, M., Akaza, T., Tadokoro, K., Kodera, Y., Sasazuki, T., Morishima, Y., and Takaku, F.
- Subjects
- *
BONE marrow transplantation , *ANTIGENS , *HLA histocompatibility antigens - Abstract
Matching of human platelet alloantigen (HPA) systems 2–6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient’s survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD. [ABSTRACT FROM AUTHOR]
- Published
- 1999
- Full Text
- View/download PDF