1. A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response
- Author
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Wen-Hui Hu, Jinhua Long, Yan Ouyang, Zuquan Hu, Zhu Zeng, Lina Liu, Shichao Zhang, Yuan-Nong Ye, Jing Zhou, Fuzhou Tang, Jin Chen, Yun Wang, Wei Qiu, Wen-Zhu Huang, and Guoqiang Xu
- Subjects
dendritic cell ,T cell ,T-Lymphocytes ,T cells ,chemical and pharmacologic phenomena ,Biology ,Lymphocyte Activation ,Applied Microbiology and Biotechnology ,immune response ,Immune system ,Cell Movement ,medicine ,T cell immunity ,Humans ,Antigens ,Molecular Biology ,Lymph node ,Ecology, Evolution, Behavior and Systematics ,Cell Proliferation ,Inflammation ,Immunity, Cellular ,Cell Biology ,Dendritic cell ,Dendritic Cells ,Models, Theoretical ,Cell biology ,medicine.anatomical_structure ,ordinary differential equations ,Immunotherapy ,Lymph Nodes ,mathematical model ,Developmental Biology ,Research Paper - Abstract
Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune responses. However, due to the complexity of the immune system, the dynamic changes in the number of cells during the peripheral tissue (e.g. skin and mucosa) immune response induced by DCs are still poorly understood. Therefore, this study simulated dynamic number changes of DCs and T cells in this process by constructing several ordinary differential equations and setting the initial conditions of the functions and parameters. The results showed that these equations could simulate dynamic numerical changes of DCs and T cells in peripheral tissue and lymph node, which was in accordance with the physiological conditions such as the duration of immune response, the proliferation rates and the motilities of DCs and T cells. This model provided a theoretical reference for studying the immunologic functions of DCs and practical guidance for the clinical DCs-based therapy against immune-related diseases.
- Published
- 2019