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The antigenic composition of the soluble extract from normal human kidney was determined with the combined techniques of immunological absorption, immuno-diffusion and immunoelectrophoresis. The kidney extract contained at least eleven non-serum, tissue antigens; some of them were found in the extracts of other organs, but three were kidney-specific. None of the soluble tissue antigens from human kidney was characterized as a lipoprotein; however, three of them stained with the reagent for glycoproteins. Esterase activities were also demonstrated in four non-serum, renal antigens, one of which was present only in the kidney extract and absent in the other organs extracts.

This article focuses on the induction of experimental glomerulonephritis in the rat by homologous major urinary protein. Few information concerning the nature, the origin and the biological function of these proteins have been acquired except the mucoprotein. In rodents, the situation was more obscure since the urinary proteins have not been intensely studied and defined as in man. Among these urinary proteins, the major one retained particularly attention because of its immunological reaction of identity with the renal component, its potent antigenicity and its large quantity in urine.