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Your search keyword '"Joshi, Shrinivas D"' showing total 2 results
Start Over Author "Joshi, Shrinivas D" Topic antimicrobial activity Topic click chemistry
2 results on '"Joshi, Shrinivas D"'

1. Microwave facilitated one-pot three component synthesis of coumarin-benzoxazole clubbed 1,2,3-triazoles: Antimicrobial evaluation, molecular docking and in silico ADME studies.

Author

Nesaragi, Aravind R., Kamble, Ravindra R., Bayannavar, Praveen K., Metre, Tukaram V., Kariduraganavar, Mahadevappa Y., Margankop, Sheetal B., Joshi, Shrinivas D., and Kumbar, Vijay M.

Subjects
MOLECULAR docking, COUMARINS, BENZOXAZOLES, MICROWAVES, ANTI-infective agents, CLICK chemistry
Abstract

4-((4-((Benzo[d]oxazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl)methyl)-2H-chromen-2-ones 7k–z were synthesized by conventional as well as microwave irradiation method in order to obtain antimicrobial agents. The present green synthetic protocol explores facile work up procedure with excellent yields (82–92%) and purity. Docking studies exhibited strong binding interactions with enzyme N-myristoyl transferase (PDB ID: 4CAW) with excellent C-score values. Compounds 7k–z were screened for their in vitro antimicrobial activities. The compounds 7w and 7 y exhibited excellent antimicrobial results for all the tested microorganisms at MICs ranging from 3.12 to 6.25 µg/ml in comparison with the marketed drugs. [ABSTRACT FROM AUTHOR]

Published
2021
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2. ChemInform Abstract: A Click Chemistry Approach for the Synthesis of Mono and Bis Aryloxy Linked Coumarinyl Triazoles as Antitubercular Agents.

Author

Anand, Ashish, Naik, Reshma J., Revankar, Hrishikesh M., Kulkarni, Manohar V., Dixit, Sheshagiri R., and Joshi, Shrinivas D.

Subjects
*COUMARINS, *CLICK chemistry, *RING formation (Chemistry)
Abstract

A wide range of mono- and bis-triazole coumarin hybrids are formed from chromene-2-one derivatives and propargyl ethers employing a Click chemistry modified protocol for Azide-Alkyne cycloadditions. [ABSTRACT FROM AUTHOR]

Published
2016
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