1. Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus
- Author
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Aaron B. Benjamin, Madeleine G. Moule, Maruti K. Didwania, Jonathan Hardy, Panatda Saenkham-Huntsinger, Preeti Sule, Josefine Eilsø Nielsen, Jennifer S. Lin, Christopher H. Contag, Annelise E. Barron, and Jeffrey D. Cirillo
- Subjects
Staphylococcus aureus ,antimicrobial peptides ,chemical synthesis ,Microbiology ,QR1-502 - Abstract
ABSTRACT Staphylococcus aureus is one of the most common pathogens associated with infection in wounds. The current standard of care uses a combination of disinfection and drainage followed by conventional antibiotics such as methicillin. Methicillin and vancomycin resistance has rendered these treatments ineffective, often causing the reemergence of infection. This study examines the use of antimicrobial peptoids (sequence-specific poly-N-substituted glycines) designed to mimic naturally occurring cationic, amphipathic host defense peptides, as an alternative to conventional antibiotics. These peptoids also show efficient and fast (
- Published
- 2022
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