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A straightforward and convergent total synthesis of (+)-antimycin A3b is reported. Four fragments were assembled on a solid support and the fully functionalized seco acid was cyclized in the solution phase. This synthetic route minimized the number of manipulations in the solution phase and is useful for a combinatorial library synthesis. [ABSTRACT FROM AUTHOR]

The cover picture shows a straightforward total synthesis of (+)‐antimycin A3b. Four fragments were assembled on a solid support, and the fully functionalized seco acid was cyclized in the solution phase. This convergent synthetic route is useful, because it minimizes the number of manipulations in the solution phase and is hence suitable for a combinatorial library synthesis. Details are discussed in the article by T. Takahashi et al. on p. 4725 ff. [ABSTRACT FROM AUTHOR]

An abstract of the article "Total Synthesis of (+)-Antimycin A3b on Solid Supports" by Osamu Kimata and colleagues is presented.