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Your search keyword '"Mendil, L."' showing total 1 results
Start Over Author "Mendil, L." Topic antineoplastic agents, immunological

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1 results on '"Mendil, L."'

1. Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.

Author

Walsh SJ, Omarjee S, Dannheim FM, Couturier DL, Bexheti D, Mendil L, Cronshaw G, Fewster T, Gregg C, Brodie C, Miller JL, Houghton R, Carroll JS, and Spring DR

Subjects
Animals, Antineoplastic Agents, Immunological adverse effects, Cell Line, Tumor, Humans, Immunoconjugates adverse effects, Mice, Proof of Concept Study, Trastuzumab adverse effects, Trastuzumab pharmacology, Xenograft Model Antitumor Assays, Antineoplastic Agents, Immunological pharmacology, Immunoconjugates chemistry, Indicators and Reagents chemistry, Pyrimidines chemistry
Abstract

The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody-drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by in vitro and in vivo evaluation of the ADCs' ability to safely and selectively eradicate target-positive tumours.

Published
2022
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