1. Conioidines A and B, novel DNA-interacting pyrrolidines from Chamaesaracha conioides.
- Author
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Chan GW, Berry D, DeBrosse CW, Hemling ME, MacKenzie-LoCasto L, Offen PH, and Westley JW
- Subjects
- Animals, Antineoplastic Agents, Phytogenic chemistry, Cattle, Cell Survival drug effects, Doxorubicin pharmacology, Humans, Hydrolysis, KB Cells, Plants, Medicinal chemistry, Pyrrolidines chemistry, Solanaceous Alkaloids chemistry, Antineoplastic Agents, Phytogenic pharmacology, DNA, Neoplasm drug effects, Pyrrolidines pharmacology, Solanaceous Alkaloids pharmacology
- Abstract
Two novel pyrrolidine compounds, conioidines A [1] and B [2], have been isolated from the Texas plant, Chamaesaracha conioides (Solanaceae). Their structures were determined by spectroscopic methods and hydrolysis studies. Both natural products, like doxorubicin, showed DNA-specific KB cell cytotoxicity. Dose-response data indicated a Kd value of 2.8 microM for binding of conioidine A [1] to calf thymus DNA.
- Published
- 1993
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