1. The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium.
- Author
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Efdi M, Itoh T, Akao Y, Nozawa Y, Koketsu M, and Ishihara H
- Subjects
- Alkaloids chemistry, Alkaloids isolation & purification, Alkaloids pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Cell Proliferation drug effects, Coumaric Acids chemistry, Coumaric Acids isolation & purification, Coumaric Acids pharmacology, Humans, Isocoumarins chemistry, Isocoumarins isolation & purification, Isocoumarins pharmacology, Lactones chemistry, Lactones isolation & purification, Naphthalenes chemistry, Naphthalenes isolation & purification, Ochratoxins chemistry, Ochratoxins isolation & purification, Ochratoxins pharmacology, Tumor Cells, Cultured, Tyramine analogs & derivatives, Tyramine chemistry, Tyramine isolation & purification, Tyramine pharmacology, Annonaceae metabolism, Antineoplastic Agents pharmacology, Lactones pharmacology, Naphthalenes pharmacology
- Abstract
Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline chloride as a quaternary alkaloid compound. The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells.
- Published
- 2007
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