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Start Over Author "Goroshinskaya IA" Topic antineoplastic agents
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1. Experimental study of structural, functional, and biochemical changes in immune organs under conditions of antitumor activity of copper nanoparticles.

Author

Shalashnaya EV, Goroshinskaya IA, Kachesova PS, Zhukova GV, Evstratova OF, Barteneva TA, Neskubina IV, and Borodulin VB

Subjects
Animals, Antineoplastic Agents chemical synthesis, Catalase metabolism, Free Radicals metabolism, Glutathione Peroxidase metabolism, Histocytochemistry, Injections, Intralesional, Injections, Intraperitoneal, Male, Malondialdehyde, Metal Nanoparticles chemistry, Particle Size, Rats, Sarcoma pathology, Spleen pathology, Splenic Neoplasms pathology, Superoxide Dismutase metabolism, Thymus Gland pathology, Tumor Burden drug effects, Antineoplastic Agents administration & dosage, Copper chemistry, Metal Nanoparticles administration & dosage, Sarcoma drug therapy, Spleen drug effects, Splenic Neoplasms drug therapy, Thymus Gland drug effects
Abstract

The effects of copper nanoparticles on the structure and function of the immune system organs (thymus and spleen) and intensity of free radical processes in the spleens of rats with sarcoma 45 were studied. A relationship between morphological and biochemical changes and antitumor efficiency of copper nanoparticles was demonstrated.

Published
2012
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