1. Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057.
- Author
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Oh M, Jang JH, Choo SJ, Kim SO, Kim JW, Ko SK, Soung NK, Lee JS, Kim CJ, Oh H, Hong YS, Ueki M, Hirota H, Osada H, Kim BY, and Ahn JS
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Benzodiazepines chemistry, Benzodiazepines isolation & purification, Benzodiazepinones chemistry, Benzodiazepinones isolation & purification, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HL-60 Cells, Hep G2 Cells, Humans, Jurkat Cells, K562 Cells, Molecular Conformation, Pyrroles chemistry, Pyrroles isolation & purification, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Benzodiazepines pharmacology, Benzodiazepinones pharmacology, Pyrroles pharmacology, Streptomyces chemistry
- Abstract
Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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