1. Non-Hodgkin's lymphoma developed during imatinib mesylate treatment of chronic myeloid leukemia.
- Author
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Kassar O, Kahla AB, Koubaa A, Kallel F, Amor IB, and Elloumi M
- Subjects
- Female, Humans, Middle Aged, Imatinib Mesylate adverse effects, Protein Kinase Inhibitors adverse effects, Rituximab therapeutic use, Treatment Outcome, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Lymphoma, Non-Hodgkin drug therapy, Lymphoma, Non-Hodgkin complications, Antineoplastic Agents adverse effects
- Abstract
Introduction: Non-Hodgkin lymphoma induced by imatinib, as a tyrosine kinase inhibitor, is a rare complication., Case Report: A 54-year-old female with a history of chronic myeloid leukemia (CML) was treated with imatinib as first-line therapy. The patient achieved a profound molecular response with treatment-free remission after five years but lost major molecular responses. A second deep molecular remission was again achieved. Nine years after imatinib therapy, the patient developed odynophagia and rhinorrhea. Physical examination revealed enlarged tonsils with a tumor-like appearance without palpable lymph nodes. Immunohistochemical examination of the tonsils revealed a large B-cell lymphoma. According to Naranjo's algorithm, the causality relationship with the drug is possible with a score of 3., Management and Outcome: Imatinib was discontinued. The lymphoma was treated with rituximab and chemotherapy., Discussion: Non-Hodgkin's lymphoma is a rare side effect of tyrosine kinase inhibitors and highlights the importance of follow-up CML patients.
- Published
- 2023
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