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1. Formal synthesis of (+)-discodermolide.

Author

Francavilla C, Chen W, and Kinder FR Jr

Subjects
Animals, Porifera chemistry, Pyrones, Stereoisomerism, Alkanes, Antineoplastic Agents chemical synthesis, Carbamates, Lactones chemical synthesis
Abstract

[structure: see text] Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C(9-18) and C(19-24) fragments via a metal-chelated aldol coupling reaction.

Published
2003
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