1. Role of humoral factors in the regulation of hemopoiesis during cytostatic-induced myelosuppression.
- Author
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Dygai AM, Zhdanov VV, Simanina EV, Gur'yantseva LA, Udut EV, Khrichkova TY, Kirienkova EV, Epstein OI, and Gol'dberg ED
- Subjects
- Animals, Antibiotics, Antineoplastic pharmacology, Blood Cells cytology, Blood Cells physiology, Erythropoietin blood, Hematopoietic Stem Cells metabolism, Mice, Mice, Inbred CBA, Antineoplastic Agents pharmacology, Doxorubicin pharmacology, Erythropoiesis drug effects, Erythropoiesis physiology, Hematopoiesis physiology
- Abstract
The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced by adriamycin in a maximum permissible dose. Cytostatic treatment affected production of substances determining erythropoietic activity by adherent and nonadherent cells of the bone marrow. Erythropoietic activity of peripheral blood plasma considerably increased. Recovery of erythroid hemopoiesis was determined by the effects of endogenous erythropoietin and other substances secreted by cells of the hemopoietic microenvironment and present in the peripheral blood.
- Published
- 2003
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