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1. Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.

Author

Lindgren, Eric B., de Brito, Monique A., Vasconcelos, Thatyana R.A., de Moraes, Manuel O., Montenegro, Raquel C., Yoneda, Julliane D., and Leal, Kátia Z.

Subjects
*ANTINEOPLASTIC agents, *BENZOTHIAZOLE, *HYDRAZONES, *CANCER cells, *CELL lines, *CHEMICAL synthesis, *IN vitro studies
Abstract

Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design. [ABSTRACT FROM AUTHOR]

Published
2014
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