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Start Over Author "Lin, Regina" Topic antineoplastic agents
1 results on '"Lin, Regina"'

1. miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment.

Author

Lin, Regina, Sampson, John H, Li, Qi-Jing, and Zhu, Bo

Subjects
*T cells, *ANTINEOPLASTIC agents, *LYMPHOCYTES, *TUMORS, *IMMUNOSUPPRESSION
Abstract

In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT. [ABSTRACT FROM PUBLISHER]

Published
2015
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