1. Graphiumisides A-D, Monoterpene Glycosides from an Animal-Derived Endophytic Fungus Graphium sp. GD-11.
- Author
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Zhang M, Zhang Y, Ji M, Li D, Wang H, Wang X, Wei W, Hui C, and Guo T
- Subjects
- Humans, Cell Line, Tumor, Animals, Cell Proliferation drug effects, Molecular Structure, Molecular Conformation, Structure-Activity Relationship, Glycosides chemistry, Glycosides pharmacology, Glycosides isolation & purification, Monoterpenes chemistry, Monoterpenes pharmacology, Monoterpenes isolation & purification, Drug Screening Assays, Antitumor, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification
- Abstract
Four new monoterpene rhamnosides, graphiumisides A-D (1-4), along with four known steroid compounds (5-8) were isolated from the fermentation extract of animal-derived endophytic fungus, Graphium sp. GD-11. The chemical structures of all compounds were elucidated using 1D and 2D NMR, HRESIMS spectroscopic analyses, and other spectroscopic methods. Compounds 1-4 exhibit a distinctive structure connected by one p-menthane type monoterpene and one L-rhamnose. This is the first report of monoterpene glycosides from Graphium sp. All compounds (1-8) were tested for cytotoxic activities against four cancer cell lines (HepG2, SMMC7721, SW480, and A549), and only compound 1 showed weak anti-tumor activity against SMMC7721 cells., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
- Published
- 2024
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