1. Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment.
- Author
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Mo Y, Liu W, Liu P, Liu Q, Yuan Z, Wang Q, Yuan D, Chen XJ, and Chen T
- Subjects
- Mice, Animals, Mice, Nude, Zebrafish, Micelles, Paclitaxel pharmacology, Drug Delivery Systems, Vitamin E pharmacology, Oligopeptides pharmacology, Cell Line, Tumor, Drug Resistance, Neoplasm, Polyethylene Glycols pharmacology, Antineoplastic Agents pharmacology, Neoplasms drug therapy
- Abstract
Background: Breast cancer (BC) has the highest global prevalence among all malignancies in women and the second highest prevalence in the overall population. Paclitaxel (PTX), a tricyclic diterpenoid, is effective against BC. However, its poor solubility in water and the allergenicity of its dissolution medium limited its clinical application., Methods: In this work, we established a multifunctional graphene oxide (GO) tumor-targeting drug delivery system using nanosized graphene oxide (nGO) modified with D-tocopherol polyethylene glycol succinate (TPGS) and arginine-glycine-aspartic acid (RGD) for PTX loading., Results: The obtained RGD-TPGS-nGO-PTX was 310.20±19.86 nm in size; the polydispersity index (PDI) and zeta potential were 0.21±0.020 and -23.42 mV, respectively. The mean drug loading capacity of RGD-TPGS-nGO-PTX was 48.78%. RGD-TPGS-nGO-PTX showed satisfactory biocompatibility and biosafety and had no significant toxic effects on zebrafish embryos. Importantly, it exerted excellent cytotoxicity against MDA-MB-231 cells, reversed multi-drug resistance (MDR) in MCF-7/ADR cells, and showed significant anti-tumor efficacy in tumor-bearing nude mice., Conclusion: These findings strongly suggested that the multifunctional GO tumor-targeting drug delivery system RGD-TPGS-nGO-PTX could be used in clinical settings to improve PTX delivery, reverse MDR and increase the therapeutic efficacy of BC treatment., Competing Interests: The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article., (© 2022 Mo et al.)
- Published
- 2022
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